E3 Grant Program

Over the past eight years, the Cardinal Health Foundation has invested over $8 million with 297 grants to hospital, health systems or other health-related organizations.

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Thank you for your interest in the Cardinal Health Foundation’s E3 – Effectiveness, Efficiency and Excellence in Healthcare Grant Program.

Cardinal Health develops and supports programs that help healthcare providers implement best practices that can truly transform patient care. Over the past nine years, the Foundation has invested $8.6 million with 297 grants to hospitals, health systems or other health-related organizations.  These projects have produced some very significant outcomes and insights.

We remain committed to helping improve the efficiency and effectiveness of healthcare and in 2017 the E3 program take into account our rapidly changing demographics, the importance of the patient and the family as key partners in care and a renewed appreciation for the value medications, when used appropriately, can play in positive patient outcomes. 

We are seeking proposals that include the following criteria in 2017:

  • Supporting the best use of medications, especially at transitions across the continuum of care from the hospital to home/to ambulatory settings.
  • Managing diabetes and/or multiple chronic diseases
  • Being informed by and implementing emerging innovations that have been tested and are supported by data showing success in improving outcomes, reducing cost or accelerating the rate of change in healthcare
  • Engaging patients and their caregivers/families as well as healthcare leadership
  • Publishing or otherwise sharing outcomes
  • Finding innovative and sustainable ways to effect long-term change

Cardinal Health E3 Grant application

In 2017 we will consider requests of $35,000 per year. Applications are due by December 9, 2016.

The request for the proposal (RFP) with specific criteria are found in the PDF on the right side of this page.  All applicants will upload responses to the RFP as a part of their application.


Download the slides from the 2017 E3 Grant Informational Webinar


E3 Grant resources

Who we are, What we do
Case Studies

E3 Summary of Case Studies

Adding pharmacy services to a multi-disciplinary discharge team (PDF)
Franciscan Alliance Foundation on behalf of Franciscan St. Margaret Health-Hammond, Mishawaka, IN

Improving outcomes for high-risk chronically ill patients (PDF)
Trinity Medical Center, Rock Island, IL
Trinitas Regional Medical Center, Elizabeth, NJ

Improving transitions to home for post-acute seniors (PDF)
Senior Independence, Toledo, OH
Senior Services of Southeastern Virginia, Norfolk, VA
Southwestern Indiana Regional Council on Aging, Inc. Evansville, IN

Increasing access for the under-insured and uninsured (PDF)
West Virginia Health Right, Charleston, WV

Increasing medication safety for older adults (PDF)
Knute Nelson Foundation, Alexandria, MN

Increasing medication safety for patients admitted from the ER (PDF)
Trinity Medical Center, Rock Island, IL

Using the WHO Surgical Safety Checklist (PDF)
NorthShore University Health System, Evanston, IL
Virginia Mason Medical Center, Seattle, WA

Learn more

E3 Grant Frequently Asked Questions

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323KB – PDF

2017 E3Grant Program Proposal Guidelines and Instructions

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239KB – PDF

2016 Recipients of E3 Patient Safety Grants

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185KB – PDF