CONTRIBUTOR

Pat Uselton, RPh
Director, Pharmacy Operations, Quality and Pharmacy Practice, Innovative Delivery Solutions, Cardinal Health
Some medications carry a higher risk of causing death or serious injury to patients than others.
Every hospital or health network should identify its high-alert medications (e.g., concentrated electrolytes, insulin, anticoagulants, opiates and chemotherapy agents) and implement processes to reduce the risk of errors for each. Pharmacy leaders should be innovative in their quest for safer medication processes, while also using those methods already proven to be effective. In this Essential Insights “Let’s Get Clinical” post, I’ll share eight high-alert medications, their common risk factors and suggested strategies for reducing the risks.
Insulin
Risk Factors
- Wrong dose administered
- Storage of multiple types of insulin in a common bin
- Confusing insulin vials with heparin vials
- Writing or allowing order sets to contain “U” for “units” (which can be interpreted as a zero)
- Programming the wrong rate into an infusion pump
Strategies for Reducing Risks
- Require an independent double-check of doses by another individual
- Do not co-mingle different types of insulin in a single bin - store in separate bins
- Store insulin and heparin separately
- Do not write or allow order sets to contain “U” for units – always spell out “units”
- Identify a small set of situations that require an independent double-check
Opiates and Narcotics
Risk Factors
- Inappropriate access to controlled substances
- Confusing HYDROmorphone and morphine
- Programming the wrong concentration and rate in infusion pumps
Strategies for Reducing Risks
- Minimize diversion by locking all controlled substances and limiting access to authorized personnel
- Use Tall Man lettering on labels, MARs, and order entry and ADC screens
- Identify a small set of situations that require an independent double-check of drugs, concentrations and rate settings on infusion pumps
Potassium Chloride/Phosphate Concentrate
Risk Factors
- Storing potassium chloride/phosphate concentrated injections in floor stock
- Preparing injectable potassium solutions in patient care areas
- Ordering unusual concentrations
Strategies for Reducing Risks
- Store injectable concentrated potassium products only in the pharmacy
- Use commercially-prepared, pre-mixed potassium products
- Standardize and limit concentrations
Intravenous Anticoagulants (Heparin)
Risk Factors
- Unclear labeling of concentration and total volume
- Miscalculation of heparin doses
- Writing “U” for “units” which can be interpreted as a zero
- Using multiple-dose containers of heparin
Strategies for Reducing Risks
- Standardize heparin concentrations and use premixed solutions only
- Do not write “U” for “units” – always spell out “units”
- Remove all 10,000 per ml heparin vials from floor stock
- Use only single-dose containers of heparin
Sodium Chloride Solutions Above 0.9%
Risk Factors
- Storing sodium chloride solutions above 0.9% in areas outside the pharmacy, including Materials Management
- Having unneeded and unusual concentrations of sodium chloride available for use (e.g., hypertonic saline in ED)
- Failing to double-check drugs and concentrations
Strategies for Reducing Risks
- Remove sodium chloride solutions above 0.9% from all locations other than the pharmacy
- Limit the number of sodium chloride concentrations available for use and stock only in the pharmacy
- Require an independent double-check of drugs and concentrations
Chemotherapy Agents
Risk Factors
- Unclear orders; use of acronyms in orders
- Miscalculation of dosing regimens
- Miscalculation of intravenous pump settings
- Dosing vinca alkaloids in syringes
Strategies for Reducing Risks
- Use approved, standardized, preprinted order forms for all chemotherapy agents
- Require patient height and weight to calculate body surface area for all chemotherapy orders
- Require an independent double-check of all dose calculations and settings for infusion pumps prior to administration
- Place doses of vinca alkaloids in piggyback dosage forms
Neuromuscular Blocking Agents
Risk Factors
- Mistaken for another drug on patient care areas
- Staff are not competent to use this type of medication
- Inadvertently used in patients without proper ventilator assistance
Strategies for Reducing Risks
- Distinctively label as a high-alert drug
- Limit storage to the pharmacy, OR, ED, and critical care units, require a prospective risk assessment such as failure mode and effects analysis (FMEA) for exceptions
- Limit access to staff with documented competence
Look-alike and Sound-alike (LASA) Drugs
Risk Factors
- Drugs with similar sounding names are often confused
- Drugs with similar looking names are often confused
Strategies for Reducing Risks
- Identify a list of pairs (no more then 10) of LASA drugs on which to concentrate
- Use distinctive lettering (e.g., TALLman lettering)
- Require physical separation in all storage areas
- Do not store in matrix drawers in ADCs
- Use different color storage bins in the pharmacy and on patient care areas
- Use distinctive, brightly-colored labels for high-alert or LASA drugs
- Require indication for use on all medication orders
- Spell out names when giving or reading back verbal orders