Clinical burnout is a serious issue particularly in the perioperative environment. The phenomenon of burnout is frequently described as an accumulation of stress causing feelings of anxiety along with symptoms that may have physical, mental, and emotional components. The cause and prevention of burnout is multifactorial, but the key attribute appears to be related to the buildup of factors that affect the realm of any or all combinations of the human body and spirit. The increasingly complex healthcare environment produces stressors and places demands on individuals and organizations that are difficult to achieve. Organizations must address the factors that are within their control to prevent burnout of their most precious commodity, their staff. This continuing education activity will describe observable characteristics associated with burnout, risk factors, and opportunities to enhance resilience and prevent burnout.