Definitions of major bleeding
||Overt bleeding including large wound hematoma with either: a documented transfusion of at least two units of RBC, a surgical revision due to bleeding or, a bleeding into critical site (intracranial, intraocular, intraarticular, retroperitoneal, overt gastrointestinal bleeding), or fatal bleeding.
||Includes any one of the following: fatal bleeding, bleeding that was retroperitoneal, intracranial, intraspinal, or involved any other critical organ; bleeding that led to reoperation; and overt bleeding with a bleeding index of >=2.
||Includes any one of the following: hemorrhage due to circulating anticoagulants; subarachnoid, intracerebral or subdural hemorrhage; unspecified hemorrhage; or gastrointestinal hemorrhage.
****Includes patients undergoing hip fracture surgery, hip replacement surgery, major knee surgery, abdominal surgery, or acutely ill high-risk medical patients receiving fondaparinux, LMWH, or placebo for VTE prophylaxis.