CAR-T Cells - The Next Era in Immuno-Oncology
In the six short years since FDA approval of the first therapy of the modern era, immuno-oncology (I-O) therapies have garnered FDA approvals in six tumor types, received indications for adjuvant, first-line metastatic and salvage disease, and been combined for dual I-O therapy.
In the next 12-18 months, I-O therapies are likely to receive an additional five tumor type approvals. Key opinion leaders believe that I-O therapies may replace chemotherapy as the backbone of modern cancer treatment. Stakeholder adoption of I-O therapies is no longer a question of “IF” but a question of “When.”
Chimeric antigen receptor (CAR)-T cells are the next frontier in this rapidly growing field. Early clinical trials demonstrate that CAR-T cells produce rapid, complete and durable responses in highly refractory patients, making this therapy a potential game-changer. However, the complexity of CAR-T synthesis and delivery, the need for wrap-around services, timing for approval and the potential reimbursement challenges may impact CAR-T’s potential for commercial success.
In this article, originally published in the American Journal of Managed Care, Dr. Bruce Feinberg, DO; Jennifer Fillman, MBA; Justin Simoncini, MBA, MPH and Chadi Nabhan, MD, MBA, FACP of Cardinal Health Specialty Solutions discuss the efficacy and toxicity of CAR-T from early clinical trial results and evaluate the potential commercial success for this therapy.
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March 2017
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Bruce Feinberg, DO
Vice President, Chief Medical OfficerCardinal Health Specialty Solutions
Jennifer Fillman
Vice President, General ManagerCardinal Health Specialty Solutions
Dr. Chadi Nabhan
Vice President and Chief Medical Officer, Cardinal Health Specialty Solutions
Justin Simoncini
Vice President Strategy, Cardinal Health Specialty Solutions
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